This learning brief, produced by USAID/PRO-WASH & SCALE, highlights the lessons learned from Apolou’s sanitation and hygiene strategies, including activities that blended community-led total sanitation (CLTS), sanitation marketing, and the clean household approach. Most notably, when communities had a blend of all three approaches the number of days from triggering to open defecation free certification reduced by 55 percent (from 720 days to 322 days). The learnings highlight the importance of multi-sectoral programming; integration, layering and sequencing; and opportunities to adapt CLTS strategies. Future programs in Karamoja would do well to focus on latrine coverage and use rather than open defecation alone; embed latrine savings schemes into saving groups; and employ holistic market-based approaches.